CCT Mrna and CREB phosphorylation upregulated by xxx in
rat hippocampus and XXXX.
Kan-yan Xu, Ying Xiong,Ming Dong, Xiu-Fang CHEN, Shanghai Institute of
Biochemistry, Shanghai Institute of Physiology, Chinese Academy of
phosphocholine cytdylyltransferase(CCT) is a key enzyme in vivo
phospholipide synthesis.So it might play an important role in the
pathogensis of neurodegenerative disease lide AD. XXXXXXXXXXX long-term
memory depended on cyclic AMP-response element binding protein, CREB.
CREB phosphorylation is essential for it’s transcriptional activity.
XXXpeptide ZNCPR and it’s analogs were indicated to have prtent
memory-enhacing activity, facilitate neurite enongation and prolongate
cell ageing, the peptide-up regulation of CCT and CREB mRNA and was
studied in this paper. ①xxx
xxxxxxxxxxxxxxxx from Western blot with specific anti-phosphorylated
CREB antibody indicated.xxxx.②By using DD-PCR and 5’ rapid amplification of cDNA ends
approaches, xxxxx xxxx cDNA xxxxx rats CCT-βwas obtained. ③The
study xx xxxx xxxxxx with reverse transcriptin PCR showed that the gene
was abundant in rat brain. Based on xxx, we now know that xxx xxxx xxxxx