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July 4, 2006 (Tuesday, Mandarin Hall)
8:30-8:45
Welcome Address
8:45-10:15
Topic I (Peptide Mimetics and Drug
Design)
Chairpersons:
James
P Tam & Jiecheng Xu
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Time
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Speaker
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Title
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8:45-9:15
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Victor
J. Hruby
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Design
of bifunctional ligands for disease: neuropathic pain (IL-01)
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9:15-9:45
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Yoshiaki
Kiso
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Challenging
intractable diseases: protease inhibitors and O¨CN
acyl migration-type prodrug forms (IL-02)
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9:45-10:15
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Shaomeng
Wang
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Design
of Smac mimetics as a new class of anticancer drugs (IL-03)
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10:15-10:30
Coffee Break
10:30-12:00
Topic I (Peptide Mimetics and Drug Design)
Chairpersons:
Saburo
Aimoto & Ziwei Huang
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Time
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Speaker
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Title
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10:30-11:00
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Kit
S Lam
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From
combinatorial chemistry to cancer targeting agents (IL-04)
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11:00-11:30
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Richard
A. Houghten
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The
use of combinatorial libraries for drug discovery (IL-05)
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11:30-11:50
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Luna
Liu
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Improved peptide
synthesis results through control of interfering solvent impurities and
reagent composition (OP-01)
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12:00-13:00
Lunch Break
Session
I: Peptide Chemistry (Mandarin Hall)
13:00-14:00
Topic II (Methodology)
Chairpersons:
Jun
Shao & Jiaxi Xu
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Time
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Speaker
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Title
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13:00-13:30
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Xumu
Zhang
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Preparation
of chiral alpha, beta and cyclic amino acids for peptide synthesis through
practical asymmetric hydrogenation (IL-06)
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13:30-14:00
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Yanxing
Jia
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Design
and synthesis of analogues of vancomycin binding pocket active against
vancomycin- resistant enterococci (VRE) (IL-07)
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14:00-15:30
Oral Presentations (Peptide Chemistry)
Chairpersons:
Hueih-Min Chen &
Ning-Hua Tan
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Time
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Speaker
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Title
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14:00-14:15
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Ya-Qiu
Long
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Discovery of a new
class of potent peptidomimetic antagonists of the grb2-SH2 domain by the
simultaneous utilization of 3¡¯-substituted tyrosine and a,a-disubstituted
amino acid (OP-03)
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14:15-14:30
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Y.
Okada
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Unique and potent
¦Ì-opioid agonists and antagonists for application to therapeutics (OP-04)
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14:30-14:45
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Michael
R. Carrasco
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"Post-translational"
modification of synthetic peptides by chemoselective alkylation of N-alkylaminooxy
amino acids (OP-05)
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14:45-15:00
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Jia-Xi
Xu
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Synthesis of
structurally diverse 2-aminoalkanesulfonic acids for synthesis of
sulfonopeptides (OP-06)
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15:00-15:15
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J.
J. Jiang
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Synthesis of
conotoxin MII and derivatives via one-pot double disulfide oxidative
refolding (OP-07)
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15:15-15:30
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Zhen
Pang
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Synthesis of small
peptides and their use as bifunctional chelating agents in diagnostic
radiopharmaceuticals (OP-08)
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15:30-15:45
Coffee Break
15:45-18:15
Oral Presentations (Peptide Chemistry)
Chairpersons:
Ya-Qiu Long & J. J.
Jiang
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Time
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Speaker
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Title
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15:45-16:00
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J.
M. Collins
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Expanding
application and scale of microwave enhanced solid phase peptide synthesis
(OP-09)
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16:00-16:15
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Sulan
Luo
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Development of
solid-phase peptide synthesis in marine medicine (OP-10)
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16:15-16:30
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Koushi
Hidaka
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Peptidemimetics
with high affinity to malarial aspartic protease plasmepsin II (OP-11)
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16:30-16:45
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Ye
Yu
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Development of
potent endomorphins analogs using a typical conformationally and
topographically constrained C-terminus (OP-12)
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16:45-17:00
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Ning-Hua
Tan
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Cyclopeptides in
plants (OP-13)
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17:00-17:15
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Qiuyun
Dai
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Design of a novel
peptidic HIV-1 fusion inhibitor against drug-resistant viruses (OP-14)
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17:15-17:30
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Hueih-Min
Chen
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A custom
anti-cancer peptide, CB1a, derived from a natural anti-microbial peptide,
cecopin B (OP-15)
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17:30-17:45
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Pu
Wang
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New special
reagents: their synthesis and application in peptide and protein chemical
syntheses (OP-16)
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17:45-18:00
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P.
W. Schiller
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Novel opioid
peptide derived antagonists containing 3-(2,6-dimethyl-4-carbamoyl)
propanoic acid (Dcp) in place of Tyr1 (OP-17)
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Session II: Peptide
Biology (3C + 3D Hall)
13:00-14:00
Topic III (Peptides and Receptors)
Chairpersons:
Kyung-Soo
Hahm & Zhongwu Guo
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Time
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Speaker
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Title
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13:00-13:30
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Songping
Liang
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A
spider peptide toxin targeting both serine proteinase and potassium
channels (IL-08)
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13:30-14:00
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Minying
Cai
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Study
of peptide vs non-peptide agonists effects on postranslational
modifications of the human melanocortin 4 receptor (IL-09)
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14:00-15:30
Oral Presentations (Peptide Biology)
Chairpersons:
Minying
Cai & Songping Liang
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Time
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Speaker
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Title
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14:00-14:15
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Hong-Yu
Hu
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The effects of GAV
homologous peptides on aggregation of a-synuclein
(OP-18)
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14:15-14:30
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L.V.
Kordyukova
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Influenza virus
membrane proteins: studying by proteomic tools (OP-19)
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14:30-14:45
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Liang
Zeng Yan
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Structure-activity
relationship of a-MSH
derived melanocortin-4 receptor agonists and its potential use as an
anti-obesity agent (OP-20)
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14:45-15:00
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Alexander
A. Zamyatnin
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Structural and
functional diversity of the natural oligopeptides (OP-21)
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15:00-15:15
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Minfen
Li
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Structural
characterization of the human Nogo functional domains and molecular design
to enhance the CNS neuronal regeneration (OP-22)
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15:15-15:30
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Jaw-Kang
Chang
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Insulin-like
peptide 5: synthesis, expression in the mouse brain and mobilization of
calcium (OP-23)
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15:30-15:45
Coffee Break
15:45-18:00
Oral Presentations (Peptide Biology)
Chairpersons:
Hong-Yu Hu & L.V.
Kordyukova
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Time
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Speaker
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Title
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15:45-16:00
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Beka
Solomon
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EFRH peptide
immunization restored cognitive functions to hAPP transgenic mice model of
Alzheimer's disease (OP-24)
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16:00-16:15
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Bih-Show
Lou
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Probing the
interaction of Na+ channel inactivation gate peptide in linker
between domain III and IV during inactivation by using NMR and ESI-MS
spectrometry (OP-25)
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16:15-16:30
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Hazel
H. Szeto
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Cell-permeable,
mitochondria-targeted antioxidant peptides are potent neuroprotective
agents (OP-26)
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16:30-16:45
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Magdalena
Witt
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Molecular
simulations of the rhodopsin tetramer (OP-27)
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16:45-17:00
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Shaoying
Wen
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A
study of the interaction of natural antimicrobial peptides with bacterial
model membrane (OP-28)
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17:00-17:15
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Jun
Lu
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Protonation-mediated
structural flexibility in the F conjugation regulatory protein, TraM (OP-29)
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17:15-17:30
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A.J.P.
ALIX
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Morpho-matrikines :
a new concept for treating the 3D interactions of matrikines from the ECM:
Applications to analogues of elastin and collagen bioactive derived
peptides (OP-30)
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17:30-17:45
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Per
Jageland
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Reversed phase HPLC
purification of peptides ¨C a case study (OP-31)
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17:45-18:00
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Ting
(Ginger) Chen
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Discovery and
characterization of human antibody inhibitors of pregnancy- associated
plasma protein-A (PAPP-A) using internally quenched synthetic peptide
substrates (OP-32)
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18:30-20:00
Dinner
20:00-21:30
Poster Presentations & Discussions
July 5, 2006 (Wednesday, Mandarin
Hall)
8:15-10:15
Topic IV (Synthesis: Large Peptides)
Chairpersons:
Ian
Smith & Yoshiaki Kiso
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Time
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Speaker
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Title
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8:15-8:45
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James
P Tam
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Cyclic
cystine-rich peptides
(IL-10)
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8:45-9:15
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Zhongwu
Guo
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Solution-phase
glycopeptide synthesis with solid-phase workup (IL-11)
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9:15-9:45
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Saburo
Aimoto
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Use
of N-S acyl shift reaction for peptide thioester preparation (IL-12)
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9:45-10:15
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Masahiko
Sisido
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tRNA
Aminoacylation Using Peptide Nucleic Acid as a Carrier of Amino Acid
Esters
(IL-13)
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10:15-10:30
Coffee Break
10:30-11:50
Topic V (Analysis and Biofunctions)
Chairpersons:
John
D. Wade & B. Moon Kim
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Time
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Speaker
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Title
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10:30-11:00
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Naoto
Minamino
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Peptidome
database and identification of new biologically active peptides (IL-14)
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11:00-11:30
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Rong
Zeng
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Detection
of phosphorylated peptides with two-dimensional liquid chromatography mass
spectrometry (IL-15)
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11:30-12:00
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Hisakazu
Mihara
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Designed peptide
microarrays for protein analyses (IL-16)
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12:00-13:00
Lunch Break
13:00-18:00
Tour
July
6, 2006 (Thursday, Mandarin
Hall)
8:15-10:15
Topic VI (Peptide Biology & SignalingChairpersons:
Jean
Martinez &
Hisakazu Mihara
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Time
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Speaker
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Title
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8:15-8:45
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Ian
Smith
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Cryptomics:
identification of novel bioactive peptides from intact proteins (IL-17)
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8:45-9:15
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B.
Moon Kim
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Development
of peptide secondary structure mimics capable of reversible structural
change through a molecular switch (IL-18)
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9:15-9:45
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John
D. Wade
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Structure-function
relationships and domain minimization of insulin-like peptide 3, a novel
member of the insulin superfamily (IL-19)
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9:45-10:15
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Rob
M. J. Liskamp
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Tools
for conformational control of peptides and mimicry of proteins: ring
closing metathesis and scaffolding (IL-20)
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10:15-10:30
Coffee Break
10:30-11:50
Topic VI (Peptide Biology & Signaling)
Chairpersons:
P. W. Schiller &
Yanmei Li
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Time
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Speaker
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Title
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10:30-11:00
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Wentworth
Jr
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Inflammatory
aldehyde triggered protein misfolding-implications from alzheimer¡¯s
disease to cancer (IL-21)
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11:00-11:30
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Kyung-Soo
Hahm
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A
Molecular Mechanism of Pore Formation by Amphipathic ¦Á-Helical
Peptides in
Lipid Membranes (IL-22)
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11:30-11:50
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Aubrey
J. Mendonca
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Polymer based
synthesis and purification of peptides (OP-02)
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12:00-13:00
Lunch Break
13:00-14:00
Topic VI (Peptide Biology & Signaling)
Chairpersons:
Keliang Liu &
Mark
Lipton
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Time
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Speaker
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Title
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13:00-13:30
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Yan-Mei
Li
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The
effects of O-phosphorylation and O-glcN- Acylation on protein structure
and function (IL-23)
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13:30-14:00
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David
J Craik
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Structure-activity
relationships and anti-HIV activity of cyclotides (IL-24)
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14:00-15:10
Special Session for
Cathay
Award
Chairpersons:
Kit
S Lam & Yunhua Ye
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Time
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Speaker
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Title
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14:00-14:35
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Jean
Martinez
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On
the use of N-carboxyanhydrides as interesting starting materials in
organic synthesis (IL-25)
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14:35-15:10
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Keliang
Liu
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Design,
synthesis and mechanism studies of long-acting peptides against protease
degradation (IL-26)
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15:10-15:25
Coffee Break
15:25-17:25
Topic VII (Synthesis: Small Peptides)
Chairpersons:
Victor
J. Hruby & Rui Wang
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Time
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Speaker
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Title
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15:25-15:55
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Takayuki
Shioiri
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Some
problems on the synthesis of biologically active cyclic peptides and
depsipeptides of aquatic origin
(IL-27)
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15:55-16:25
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Madeleine
M. Joulli¨¦
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Synthetic
investigations of antimitotic agents (IL-28)
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16:25-16:55
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Mark
Lipton
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Solid-phase
synthesis and mode of action studies of the cyclic depsipeptides
callipeltins A and B (IL-29)
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16:55-17:25
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Zhu-Jun
Yao
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Studies
on total synthesis of chlorofusin, a naturally occurring p53-MDM2
interaction inhibitor (IL-30)
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17:25
Award Ceremony and Closing Remarks
18:30
Farewell Banquet
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