July 4, 2006 (Tuesday, Mandarin Hall)

 8:30-8:45                  Welcome Address

8:45-10:15                Topic I (Peptide Mimetics and Drug Design)

Chairpersons: James P Tam & Jiecheng Xu

Time

Speaker

Title

8:45-9:15

Victor J. Hruby

Design of bifunctional ligands for disease: neuropathic pain (IL-01)

9:15-9:45

Yoshiaki Kiso

Challenging intractable diseases: protease inhibitors and OCN acyl migration-type prodrug forms (IL-02)

9:45-10:15

Shaomeng Wang

Design of Smac mimetics as a new class of anticancer drugs (IL-03)

 10:15-10:30               Coffee Break  

10:30-12:00              Topic I (Peptide Mimetics and Drug Design)  

Chairpersons: Saburo Aimoto & Ziwei Huang

Time

Speaker

Title

10:30-11:00

Kit S Lam

From combinatorial chemistry to cancer targeting agents (IL-04)

11:00-11:30

Richard A. Houghten

The use of combinatorial libraries for drug discovery (IL-05)

11:30-11:50

Luna Liu

 

Improved peptide synthesis results through control of interfering solvent impurities and reagent composition (OP-01)

12:00-13:00               Lunch Break

Session I: Peptide Chemistry (Mandarin Hall)

13:00-14:00              Topic II (Methodology)

Chairpersons: Jun Shao & Jiaxi Xu

Time

Speaker

Title

13:00-13:30

Xumu Zhang

Preparation of chiral alpha, beta and cyclic amino acids for peptide synthesis through practical asymmetric hydrogenation (IL-06)

13:30-14:00

Yanxing Jia

Design and synthesis of analogues of vancomycin binding pocket active against vancomycin- resistant enterococci (VRE) (IL-07)

14:00-15:30              Oral Presentations (Peptide Chemistry)

Chairpersons: Hueih-Min Chen & Ning-Hua Tan

Time

Speaker

Title

14:00-14:15

Ya-Qiu Long

Discovery of a new class of potent peptidomimetic antagonists of the grb2-SH2 domain by the simultaneous utilization of 3-substituted tyrosine and a,a-disubstituted amino acid (OP-03)

14:15-14:30

Y. Okada

Unique and potent -opioid agonists and antagonists for application to therapeutics (OP-04)

14:30-14:45

Michael R. Carrasco

 

"Post-translational" modification of synthetic peptides by chemoselective alkylation of N-alkylaminooxy amino acids (OP-05)

14:45-15:00

Jia-Xi Xu

 

Synthesis of structurally diverse 2-aminoalkanesulfonic acids for synthesis of sulfonopeptides (OP-06)

15:00-15:15

J. J. Jiang

 

Synthesis of conotoxin MII and derivatives via one-pot double disulfide oxidative refolding (OP-07)

15:15-15:30

Zhen Pang

 

Synthesis of small peptides and their use as bifunctional chelating agents in diagnostic radiopharmaceuticals (OP-08)

15:30-15:45               Coffee Break

15:45-18:15              Oral Presentations (Peptide Chemistry)

Chairpersons: Ya-Qiu Long & J. J. Jiang

Time

Speaker

Title

15:45-16:00

J. M. Collins

Expanding application and scale of microwave enhanced solid phase peptide synthesis (OP-09)

16:00-16:15

Sulan Luo

Development of solid-phase peptide synthesis in marine medicine (OP-10)

16:15-16:30

Koushi Hidaka

Peptidemimetics with high affinity to malarial aspartic protease plasmepsin II (OP-11)

16:30-16:45

Ye Yu

Development of potent endomorphins analogs using a typical conformationally and topographically constrained C-terminus (OP-12)

16:45-17:00

Ning-Hua Tan

Cyclopeptides in plants (OP-13)

17:00-17:15

Qiuyun Dai

 

Design of a novel peptidic HIV-1 fusion inhibitor against drug-resistant viruses (OP-14)

17:15-17:30

Hueih-Min Chen

A custom anti-cancer peptide, CB1a, derived from a natural anti-microbial peptide, cecopin B (OP-15)

17:30-17:45

Pu Wang

New special reagents: their synthesis and application in peptide and protein chemical syntheses (OP-16)

17:45-18:00

P. W. Schiller

Novel opioid peptide derived antagonists containing 3-(2,6-dimethyl-4-carbamoyl) propanoic acid (Dcp) in place of Tyr1 (OP-17)

 Session II: Peptide Biology (3C + 3D Hall)